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Metformin is a well-known oral medication traditionally used to manage type 2 diabetes. In recent years, it has gained recognition in longevity and anti-aging medicine due to its impact on insulin sensitivity, mitochondrial health, inflammation, and cellular aging. As a caloric restriction mimetic, Metformin is now widely used off-label to support metabolic health, fat loss, and cellular resilience, with potential to reduce age-related diseases and improve health span.
Benefits:Enhances insulin sensitivity and stabilizes blood sugarMay reduce visceral fat and improve body compositionSupports mitochondrial function and metabolic flexibilityMay reduce the risk of age-related diseases (heart disease, cancer, cognitive decline)Activates cellular repair pathways (AMPK, autophagy)
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Metformin targets multiple aging-related pathways through metabolic regulation and mitochondrial support:
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Common (Typically transient):
• Nausea
• Diarrhea
• Gas or bloating
• Metallic taste
Less Common / Monitor If Present:
• Vitamin B12 deficiency (check annually)
• Lactic acidosis (rare; risk higher in kidney/liver impairment or alcohol abuse)
• Decreased appetite or mild fatigue
Precautions:
