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What is Rapamycin ?
Rapamycin (Sirolimus)is an mTOR inhibitor traditionally used as an immunosuppressant in transplant medicine. In recent years, it has gained growing interest in the field of longevity and anti-aging medicine due to its ability to modulate cellular aging, inflammation, and metabolic health. When dosed intermittently and at low levels, Rapamycin may help extend lifespan, delay age-related disease onset, and support health span without the immune suppression associated with high-dose use.
Benefits:
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How does it work ?
Rapamycin works by selectively inhibiting the mammalian target of rapamycin complex 1 (mTORC1), a key regulator of aging and growth:
mTORC1 Inhibition
• mTORC1 controls cell growth, proliferation, and protein synthesis. Rapamycin slows this pathway, promoting cellular repair, autophagy, and metabolic efficiency—hallmarks of anti-aging.
Intermittent, Low-Dose Strategy
• When used once or twice weekly at low doses, it avoids immunosuppression while preserving its anti-aging and regenerative benefits.
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Common (Usually mild at low/intermittent doses):
• Mouth ulcers or canker sores
• Gastrointestinal discomfort
• Headache or fatigue
• Mild immunosuppression (dose-dependent)
Less Common / Monitor If Present:
• Elevated triglycerides or cholesterol
• Impaired wound healing
• Increased risk of infection at high doses
• Menstrual irregularities
